Indianapolis Colts pulled off the upset to defeat San Francisco 49ers. Indianapolis Colts entered the game as the underdog, with a 39% chance to win before the game started.
From the outset, Indianapolis Colts refused to go away, chipping away at San Francisco 49ers's lead until Indianapolis Colts took their first lead during the middle stretches of the game. San Francisco 49ers never recovered after losing the lead, and by the time the game ended, Indianapolis Colts had earned the upset.